Spectra 10 with lyme7/21/2023 ![]() ![]() The dbpA of strain N40-D10/E9 conferred the weakest decorin- and GAG-binding activity, but the most robust joint colonization and was the only dbpA allele capable of conferring significant joint disease. garinii strain PBr conferred the greatest decorin- and dermatan sulfate-binding activity, promoted the greatest colonization at the inoculation site and heart, and caused the most severe carditis. ![]() burgdorferi strain N40-D10/E9, dbpA of B. burgdorferi strains that encode different dbpA alleles. To directly test whether variation in dbpA influences tissue tropism, we analyzed murine infection by isogenic B. DbpA variants differ in their ability to bind to its host ligands and to cultured mammalian cells. The attachment of microbial pathogens to cells or to the extracellular matrix of target tissues may promote colonization and disease, and the Lyme disease spirochete encodes several surface proteins, including the decorin- and dermatan sulfate-binding adhesin DbpA, which vary among strains and have been postulated to contribute to strain-specific differences in tissue tropism. Borrelia burgdorferi sensu stricto, the most common Lyme spirochete in the U.S., is closely associated with arthritis. afzelii, are each most commonly associated with overlapping but distinct spectra of clinical manifestations. For example, the three major Lyme disease spirochete species, Borrelia burgdorferi sensu stricto, B. Lyme disease spirochetes demonstrate strain- and species-specific differences in tissue tropism. ![]()
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